Author/Editor		Štor, Z; Frković-Grazio, S; Bračko, M; Repše, S
Title		Prognostic value of clinical, pathological and immunohistochemical markers in stage II colon cancer patients
Type		članek
Source		Acta Chir Iugosl
Vol. and No.		Letnik 55, št. 3
Publication year		2008
Volume		str. 39-44
Language		eng
Abstract		Background/Aims: The purpose of our analysis was to determine the prognostic value of molecular markers for identifying high-risk TNM stage colon cancer patients, the association with various clinical and pathological features, and possible relation to survival. Methods: In 191 colon cancer patients who underwent a potentially curafive resection, clinical and pathological factors (age, tumour site, histological grade of malignancy, pT stage, presence of venous, lymphatic and perineural invasion) and tumour molecular markers were analysed. Molecular markers were assessed immunohistochemically in sections of paraffin-embedded tissues. Patients were followed for a median of 8.7 years. The 5-year survival rate was estimated using the the Kaplan-Meier statistical method. Results: From 1. Jan.1994 to 31.Dec.2000, 191 patients underwent radical resection for T3-4 NOMO colorectal cancer without adjuvant chemotherapy. A significant decrease in survival was identified in older patients, patients with tumours pT4 and with perineural invasion. We found no significant differences in survival of patients with expression of MLHl, Cyclin DI and reduced overexpression of E-cadherin. Conclusions: The results of our study indicate that the presence of perineural invasion, pT4 stage and the patient's age are significantly correlated with the expected survival in radically resected TNM stage II colon cancer patients, while immunohistochemical markers are not related to survival.
Descriptors		COLORECTAL NEOPLASMS NEOPLASM STAGING IMMUNOHISTOCHEMISTRY PROGNOSIS SURVIVAL ANALYSIS