Author/Editor		Levin, JM; Nelson, JA; Segreti, J; Harrison, B; Benson, CA; Strle, F
Title		In vitro susceptibility of Borrelia burgdorferi to 11 antimicrobial agents
Type		članek
Source		Antimicrob Agents Chemother
Vol. and No.		Letnik 37, št. 7
Publication year		1993
Volume		str. 1444-6
Language		eng
Abstract		The in vitro susceptibility of Borrelia burgdorferi to 11 antimicrobial agents was investigated. The antimicrobial agents evaluated included ceftizoxime, FK037, cefotaxime, dirithromycin, clarithromycin and its metabolite 14-hydroxy-clarithromycin, erythromycin, doxycycline, amoxicillin, ciprofloxacin, and ofloxacin. Isolates of B. burgdorferi tested included two reference strains (B31 and ATCC 53899), six isolates from the midwestern United States, and three from Europe. A broth macrodilution method was used to determine MICs and MBCs. B. burgdorferi was inhibited by less th. or = 0.5 micrograms of each of the agents except the quinolones per ml. The MBCs for 90 percent of strains tested of ceftizoxime, FK037, clarithromycin, 14-OH clarithromycin, and dirithromycin ( less th. or = 1.0 microgram of each per ml) were superior to those of amoxicillin (2.0 micrograms/ml) and doxycycline (4.0 micrograms/ml). Further in vivo studies are warranted to determine whether these agents may be efficacious in the treatment of Lyme borreliosis.
Descriptors		ANTIBIOTICS BORRELIA BURGDORFERI ANTIBIOTICS, MACROLIDE CEPHALOSPORINS CIPROFLOXACIN MICROBIAL SENSITIVITY TESTS OFLOXACIN