Author/Editor		Stern, MH; Soulier, J; Rosenzwajg, M; Nakahara, K; Canki-Klain, N; Aurias, A; Sigaux, F; Kirsch, IR
Title		MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations
Type		članek
Source		Oncogene
Vol. and No.		Letnik 8, št. 9
Publication year		1993
Volume		str. 2475-83
Language		eng
Abstract		T-cell lymphoproliferative diseases are often associated with recurrent chromosomal translocations involving T cell receptor genes (TCR) and genes that are thought to play a role in the pathogenesis of these diseases. Whereas numerous such genes have already been identified in acute T cell leukemias, no candidate gene has yet been identified to play a role in the heterogeneous group of T cell proliferations with a mature phenotype. We here report the molecular cloning of two examples of the rare but recurrent t(X;14) translocation. The first translocation was associated with a benign clonal proliferation in an ataxia telangiectasia patient and the second with a T cell prolymphocytic leukemia. Both translocations implicated the TCR alpha/delta locus and a common breakpoint region on chromosome Xq28. A previously unidentified gene, abnormally transcribed in both T cell proliferations, was characterized in the immediate proximity of the breakpoints. This Xq28 gene has no homology with known sequences, uses a complex alternative splicing pattern and demonstrates two short open reading frames. This gene, named MTCP-1 (Mature T Cell Proliferation-1) is the first candidate gene potentially involved in the leukemogenic process of mature T cell proliferations.
Descriptors		LYMPHOPROLIFERATIVE DISORDERS PROTO-ONCOGENE PROTEINS RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA TRANSLOCATION (GENETICS) X CHROMOSOME ALTERNATIVE SPLICING AMINO ACID SEQUENCE ATAXIA TELANGIECTASIA BASE SEQUENCE CHROMOSOMES, HUMAN, PAIR 14 GENE EXPRESSION GENES, STRUCTURAL LEUKEMIA, PROLYMPHOCYTIC MOLECULAR SEQUENCE DATA RESTRICTION MAPPING RNA, MESSENGER T-LYMPHOCYTES