Author/Editor		Bulc-Rozman, Klara; Šuput, Dušan; Molgo, Jordi; Benoit, Evelyne
Title		Cnidarian toxins acting on the cholinergic system
Type		članek
Source		In: Benoit E, Goudey-Perriere F, Marchot P, et al, editors. Toxines et fonctions cholinergiques neuronales et non neuronales. Paris: Societe Francaise pour l'Etude des Toxines (SFET),
Publication year		2008
Volume		str. 19-22
Language		eng
Abstract		Cnidarian toxins, especially toxins from corals, comprise a great number of diverse substances including proteins and secondary metabolites. Only a small portion of those substances has been pharmacologically well characterized and, despite the richness and diversity of cnidarian toxins, only a few studies have been dealing with those acting on the cholinergic system. Here, we describe cnidarian toxins acting on acetylcholine receptors, acetylcholinesterase and choline acetyltransferase. The search in the literature revealed no report on cnidarian toxins acting directly on vesicular transport or exocytosis of acetylcholine, except for some toxins that act either on K+ current or intracellular Ca2+ activity in nerve terminals, which is beyond the scope of this review. The possible use of cnidarian toxins acting on the cholinergic system in the treatment of neurodegenerative disorders is also described.
Descriptors		CNIDARIAN VENOMS CHOLINERGIC FIBERS RECEPTORS, CHOLINERGIC ACETYLCHOLINESTERASE CHOLINE ACETYLTRANSFERASE CNIDARIA