| Author/Editor | Černelč, P | |
| Title | Uporaba v hematologiji dejavnika (GM-CSF), ki pospešuje nastanek granulocitov in makrofagov | |
| Translated title | The use of granulocyte-macrophage colony-stimulating factor (GM-CSF) in haematology | |
| Type | članek | |
| Source | Zdrav Vestn | |
| Vol. and No. | Letnik 62, št. 9 | |
| Publication year | 1993 | |
| Volume | str. 367-71 | |
| Language | slo | |
| Abstract | Background. The human recombinant GM-CSF (rhGM-CSF) has been used successfuly to raise neutrophil count and prevent or control infection in patients with neutropenia due to aplastic anemia, myelokathexis, myelodysplastic syndrome, chemotherapy and/or radiotherapy in acute leukaemia and bone marrow transplantation. Methods and results. In a patient with myelokathexis absolute neutrophil count (ANC) in the peripheral blood increased to normal value after 2 h after subcutaneous injection of 5 ug/kg rhGM-CSF (Leucomax, Sandoz/Schering-Plough) or rhG-CSF (Neupogen, Amgen/F.Hoffmann-La Roche), and returned to its previous level 49-72 h after the injection of rhCSF. In 2 elderly pts with acute myeloblastic leukaemia (AML) who were neuthropenic after intensive chemotherapy TAD (6-thioguanine, cytarabine, daunorubicin) 5 ug/kg rhGM-CSF was given after chemotherapy subcutaneously once daily. ANC increased up to O.5 x 109/L after 16 and 19 days, up to 1.8 x 109/L after 18 and 21 days. In control group of pts with AML ANC increased up to O.5 x l09/L after 21 days, and up to 1.8 x 109/L after 27 days. RhGM-CSF accelerated the recovery of neutrophils by approximately 6 days. In 1pt with aplastic anemia (AA) and 1pt with acute lymphoblastic leukaemia (ALL) 5 ug/kg rhGM-CSF was given after allogeneic bone marrow transplantation subcutaneously once daily. ANC increased up to 0.5 x 109/L after 16 and 17 days. In a control group of 6 pts after allogeneic bone marrow transplantation ANC increased up to 0.5 x 109/L after 22 days. RhGM-CSF accelerated the marrow transplantation. recovery of neutrophils by approximately 5 days. In 1 pt with AML who was neutropenic after intensive chemotherapy and 1 pt with ALL after allogeneic bone marrow transplantation rhGM-CSF therapy were discontinued because of adverse effects were. Conclusions.(trunc.) | |
| Descriptors | GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR NEUTROPENIA ANEMIA, APLASTIC LEUKEMIA LEUKEMIA BONE MARROW TRANSPLANTATION |