Author/Editor		Lundgren, Stina; Andersen, Birgit; Piškur, Jure; Dobritzsch, Doreen
Title		Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster
Type		članek
Source		Acta Cryst Sec F
Vol. and No.		Letnik 63, št. Pt 10
Publication year		2007
Volume		str. 874-7
Language		eng
Abstract		Beta-alanine synthase catalyzes the last step in the reductive degradation pathway for uracil and thymine, which represents the main clearance route for the widely used anticancer drug 5-fluorouracil. Crystals of the recombinant enzyme from Drosophila melanogaster, which is closely related to the human enzyme, were obtained by the hanging-drop vapour-diffusion method. They diffracted to 3.3 A at a synchrotron-radiation source, belong to space group C2 (unit-cell parameters a = 278.9, b = 95.0, c = 199.3 A, beta = 125.8 degrees) and contain 8-10 molecules per asymmetric unit.
Descriptors		AMIDOHYDROLASES ANIMALS CRYSTALLIZATION CRYSTALLOGRAPHY, X-RAY DROSOPHILA MELANOGASTER