Author/Editor		Clausen, AR; Matakos, A; Sandrini, MP; Piškur, J
Title		Thymidine kinases in archaea
Type		članek
Source		Nucleosides Nucleotides Nucleic Acids
Vol. and No.		Letnik 25, št. 9-11
Publication year		2006
Volume		str. 1159-63
Language		eng
Abstract		Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum. The identified TK1s have high identity to Gram-positive bacteria TK1s. The TK1s from archaea, Gram-positive bacteria and eukaryotes share the same common ancestor, while the TK1s from Gram-negative bacteria belong to a less-related subgroup. It seems that a functional deoxyribonucleoside salvage pathway is not crucial for the archaeal cell.
Descriptors		GENE EXPRESSION REGULATION AMINO ACID SEQUENCE ANIMALS BACTERIAL PROTEINS EVOLUTION, MOLECULAR MOLECULAR SEQUENCE DATA PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR) PHYLOGENY SPECIES SPECIFICITY THYMIDINE KINASE