Author/Editor		Sandrini, MP; Clausen, AR; Munch-Petersen, B; Piškur, J
Title		Thymidine kinase diversity in bacteria
Type		članek
Source		Nucleosides Nucleotides Nucleic Acids
Vol. and No.		Letnik 25, št. 9-11
Publication year		2006
Volume		str. 1153-8
Language		eng
Abstract		Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.
Descriptors		GENE EXPRESSION REGULATION, BACTERIAL AMINO ACID SEQUENCE BACTERIA EVOLUTION, MOLECULAR MODELS, MOLECULAR MOLECULAR SEQUENCE DATA NUCLEOSIDES OPEN READING FRAMES PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR) PHYLOGENY PYRIMIDINES SEQUENCE HOMOLOGY, AMINO ACID SPECIES SPECIFICITY THYMIDINE KINASE