Author/Editor		Piškur, Jure; Sandrini, Michael P; Knecht, Wolfgang; Munch-Petersen, Birgitte
Title		Animal deoxyribonucleoside kinases: 'forward' and 'retrograde' evolution of their substrate specificity
Type		članek
Source		FEBS Lett
Vol. and No.		Letnik 560, št. 1-3
Publication year		2004
Volume		str. 3-6
Language		eng
Abstract		Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to study gene duplication and specialisation of the duplicated copies through partitioning of substrate specificity. Recent studies suggest that in the animal lineage one of the progenitor kinases, the so-called dCK/dGK/TK2-like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.
Descriptors		EVOLUTION, MOLECULAR AMINO ACID SEQUENCE ANIMALS CONSERVED SEQUENCE DNA MOLECULAR SEQUENCE DATA NUCLEIC ACID PRECURSORS PHOSPHORYLATION PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR) PHYLOGENY POINT MUTATION SEQUENCE HOMOLOGY, AMINO ACID STRUCTURE-ACTIVITY RELATIONSHIP SUBSTRATE SPECIFICITY