Author/Editor		Fommei, Enza; Mazzasalma, Lorena; Ghione, Sergio; Volterrani, Duccio; Oei, Yoe; Hilson, Andrew JW; Carrieri, Marilisa; Jezeršek, P
Title		European captopril radionuclide test multicenter study. Preliminary results: inspective renographic analysis
Type		članek
Source		Am J Hypertens
Vol. and No.		Letnik 4, št. 12
Publication year		1991
Volume		str. 690S-7S
Language		eng
Abstract		Captopril radionuclide test (CRT) has been introduced in clinical practice as a screening test for renovascular hypertension, since it allows the detection of the decrease of glomerular filtration rate that may be induced by angiotensin converting enzyme inhibition (25 mg oral captopril) in kidneys ipsilateral to a renal artery stenosis. However, due to the low prevalence of the disease, experiences in single centers may hardly satisfy the need for representative series of patients to validate the test. Nineteen centers participated in a collaborative study (CRT European Multicenter Study) that collected data from 424 patients. Here we report on the first results obtained by inspective renographic analysis. The captopril radionuclide test greatly potentiated the diagnostic performance of conventional renography and the accuracy was maximal when relying simply on postcaptopril findings alone. Specificity was 84.1 per cent in the overall population and 91.8 per cent in uncomplicated patients without nephropathy and renal insufficiency. Taking into account the sole arteriographic diagnosis, sensitivity was 73.2 per cent or 90.7 per cent for the subjects with unilateral or bilateral stenosis and an angiographic degree of stenosis = 70 per cent . On the other hand, when a successful outcome of blood pressure after revascularization or nephrectomy was considered as the gold standard for the diagnosis of renovascular hypertension, a high sensitivity was obtained (92.7 per cent ). Moreover, the test became negative after intervention in the great ma jority (88 per cent ) of patients who had a positive preintervention CRT and a normalization of blood pressure after revascularization.(trunc.)
Descriptors		HYPERTENSION, RENOVASCULAR CAPTOPRIL RADIOISOTOPE RENOGRAPHY EUROPE ADULT AGED BLOOD PRESSURE MULTICENTER STUDIES SENSITIVITY AND SPECIFICITY