Author/Editor		Zidar, N; Ferluga, D; Volavšek, M; Vizjak, A; Luzar, S; Kveder, R
Title		Renal extraglomerular vascular immune deposits in IgA glomerulonephritis
Type		članek
Source		Kidney Int
Vol. and No.		Letnik 42, št. 6
Publication year		1992
Volume		str. 1444-9
Language		eng
Abstract		Renal extraglomerular vascular immune deposits in IgA glomerulonephritis. Kidney biopsies of 425 patients with IgA glomerulonephritis were studied to reveal the incidence, composition and possible clinical significance of extraglomerular vascular immune deposits. IgA deposits were detected in 20 cases, IgM in 28 (in 5 together with IgA), C3 in 317 and no vascular deposits in 60 cases. C3 and Ig.4 deposits were granular, resembling mesangial deposits, while IgM deposits were lumpy, similar to IgM deposits in sclerotic and hyalinized glomeruli. The incidence of vascular lesions in patients with IgA (30 per cent ) and C3 deposits (24 per cent ) was not significantly higher as compared to those without vascular deposits (20 per cent ), but was significantly higher in patients with 1gM deposits (68 per cent , P less th. 0.00004). Only the presence of vascular IgM deposits correlated significantly with severe glomerulosclerosis, arterial hypertension and elevated serum creatinine levels (all P less th. 0.001). We conclude that neither C3 nor IgA deposits, in spite oftheir suggested immune complex nature, contribute significantly to the development of vascular lesions. Lumpy IgM deposits. probably the result of insudation of plasma proteins into the blood vessel walls, were associated with advanced vascular lesions and glomerulosclerosis and are probably a part of non-immune mediated progression of IgA glomerulonephritis.
Descriptors		ANTIGEN-ANTIBODY COMPLEX GLOMERULONEPHRITIS, IGA ADULT COMPLEMENT 3 FLUORESCENT ANTIBODY TECHNIQUE GLOMERULONEPHRITIS, IGA GLOMERULONEPHRITIS, IGA GLOMERULOSCLEROSIS, FOCAL GLOMERULOSCLEROSIS, FOCAL GLOMERULOSCLEROSIS, FOCAL IgA IgM KIDNEY KIDNEY MIDDLE AGE