Author/Editor		Šušteršič, Miha; Bunc, Matjaž
Title		Nova spoznanja o reninsko-angiotenzisko-aldosteronskem sistemu in nove strategije njegove zavore
Translated title		New knowledge of renin-angiotensin-aldosterone system and new strategies of its blockade
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 47, št. 4
Publication year		2008
Volume		str. 379-90
Language		slo
Abstract		The renin-angiotensin-aldosterone system is a hormone system chat is vital for the regulation of arterial blood pressure, electrolyte balance and extracellular fluid volume in the body. Since the discovery of renin in 1898 and later the renin-angiotensin-aldostcronc system, there have been numerous studies on its effects and influences on physiological and pathophysiological mechanisms in different organs. The classical renin-angiotensin-aldosterone system pathway that begins with the release of renin from the kidneys, through angiotensin-I, angiotensin-II and aldosteroneformation is a widely known concept that could now be described as incomplete. There is increasing evidence of the existence of a tissue renin-angiotensin-aldosterone system but it has been unsatisfactorily blocked with the blocking strategies known to dace. The objective of this paper is to address new knowledge about the renin-angiotensin-aldosterone system and new strategies for its blockage.
Descriptors		RENIN-ANGIOTENSIN SYSTEM ALDOSTERONE ANGIOTENSINS HYPERTENSION ANGIOTENSIN-CONVERTING ENZYME INHIBITORS RECEPTORS, ANGIOTENSIN RECEPTORS, MINERALOCORTICOID