Author/Editor		Jan, Žiga; Virant-Klun, Irma; Peterlin, Borut; Zorn, Branko
Title		Vpliv epigenskih modifikacij na razvoj in funkcijo moške gamete
Translated title		Effects of epigenetic modifications on male gamete development and function
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 47, št. 4
Publication year		2008
Volume		str. 341-53
Language		slo
Abstract		Epigenetic DNA modifications participate in genome regulation. These marks modulate the gene expression pattern and, on the whole genome scale, provide a cell-specific expression profile.'fhey are pivotal to development, as they first enable preimplantation embryo pluripotency and, later on, cell differentiation.13ecause these marks are dynamic, they allow for the development of germ cell. In this review, DNA methylation, histone modifications and RNA interference are presented and their possible role in male germ cell development is discussed. Some early evidence linking erroneous epigenetic marks to male gamete (spermatozoon) dysfunction is also presented.
Descriptors		SPERMATOGENESIS DNA METHYLATION GENE EXPRESSION HISTONES GENOMIC IMPRINTING