Author/Editor		Gorišek, Borut; Rebolj-Stare, Marija
Title		Histological types and papilar growth patern in borderline ovarian tumors: a retrospective study
Translated title		Histološki tipi in papilarna rast pri mejno malignih tumorjih jajčnika: retrospektivna raziskava
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 78, št. 3
Publication year		2009
Volume		str. 113-7
Language		eng
Abstract		Background. Our retrospective study was carried out with the aim of establishing the percentage of histologic types in borderline ovarian tumors (BLOT), bilateralism and the presence of papillary growth according to individual types. Methods. The study included 55 women treated at Maribor Teaching Hospital between January 1st, 1993 and December 31st, 2001. Data were collected up to April 1st, 2005. Results. Serous BLOT prevailed (74.5%) while the number of mucinous BLOT was smaller (21.8%). Borderline ovarian tumors were bilateral in 20% of women and unilateral in 80%. Among bilateral BLOT the serous type prevailed (90.9%) while the mucinous were bilateral less often (9.1%). Of the bilateral BLOT as many as 63.6 % were in stage II-IV. Papillary growth was found in 40 % of BLOT, 95.45% of them were of the serous and only 4.45% of the mucinous type. A statistically significant connection was established between the serous histologic type of BLOT and papillary structure (P = 0.004). Conclusions. Borderline ovarian tumors are mostly serous, one fourth are bilateral and more than one half have papillary growth. Serous BLOT involve peritoneal implants and positive pelvic lymph nodes more often than the mucinous. Mucinous BLOT were mostly unilateral, rarely with papillary growth, and with negative lymph nodes.
Summary		Problem mejno malignih ovarijskih tumorjev (BLOT) je prvič izpostavil Taylor leta 1929, ko je opisal podvrsto ovarijskih tumorjev in jih označil za semimaligne. Svetovna zdravstvena organizacija (WHO) in Mednarodna organizacija za ginekologijo in porodništvo (FIGO) sta jih opredelila kot posebno podskupino ovarijskih tumorjev šele v začetku 70. let 20. stoletja. Predstavljajo 10.20% vseh epitelnih ovarijskih tumorjev. Imajo nizek maligni potencial in počasno rast. Najpogostejši so serozni in mucinozni. Bolnice z BLOT imajo relativno dobro napoved, le manjša skupina ima slabšo. Zato je dobro poznati dejavnike, ki nam omogočajo, da te bolnice s slabšo prognozo prepoznamo in dodatno zdravimo. Z retrospektivno raziskavo smo želeli ugotoviti delež histoloških tipov mejno malignih tumorjev jajčnika (BLOT), bilateralnost ter prisotnost papilarne rasti po posameznih tipih. Metode. V raziskavo je bilo vključenih 55 bolnic, ki so bile v obdobju 1.1.1993 - 31.12.2001 zdravljene v Učni bolnišnici Maribor. Uporabo podatkov za statistie nenamene so vse bolnice dovolile. Redno smo jih spremljali v Ambulanti za onkologijo. Zbrali smo podatke do 1.4.2005. Rezultati. Vključene so bile vse bolnice. Stare so bile od 18 - 87 let, z mediano 48 let in povprečno starostjo 50,7 +- 16,7 leta. Sledenje bolnic je trajalo od 9 - 145 mesecev, povprečno 76,73 +- 4,59 meseca, mediana 73 mesecev. Po histološkem izvidu smo bolnice razdelili v skupine s seroznim (74,54%), mucinoznim (21,82%) in drugimi (Sertoli-Leydig, mešani epitelni) histološkimi tipi (3,64%). Prevladoval je serozni tip BLOT (74,5%), manj je bilo mucinoznega (21,8%). Mejno maligni tumorji jajčnika so bili obojestranski pri 20% bolnic in enostranski pri 80%. Obojestranski so bili predvsem seroznega tipa (90,9%) in manj mucinoznega (9,1%). Kar 63,6% obojestranskega BLOT je bilo pri stadiju II-IV. (Izvleček skrajšan pri 2000 znakih)
Descriptors		OVARIAN NEOPLASMS PAPILLOMA RETROSPECTIVE STUDIES