Author/Editor		Bajuk-Studen, Katica; Preželj, Janez; Kocjan, Tomaž; Pfeifer, Marija
Title		Mehanizmi srčno-žilne orgroženosti žensk s sindormom policističnih ovarijev
Translated title		Mechanisms of cardiovascular disease risks in women with polycystic ovary syndrome
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 78, št. 3
Publication year		2009
Volume		str. 129-35
Language		slo
Abstract		Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. The main features of the syndrome are clinical and/or laboratory signs of hyperandrogenism and menstrual cycle irregularities, although several variants of the definition of the syndrome exist. Conclusions PCOS is clearly associated with increased prevalence of cardiovascular disease risk factors. However, long term risk of cardiovascular disease morbidity and mortality is not yet clear. Reciprocal relationships between endothelial dysfunction, early pre-clinical form of atherosclerosis, and insulin resistance, key metabolic disturbance in PCOS, mark the pathogenesis of atherosclerosis in PCOS. The role of the renin-angiotensin-aldosterone system has been partially elucidated. More than half of PCOS patients are obese with increased visceral adipose tissue accumulation. Adipose tissue is an important endocrine organ, releasing many metabolically active substances ‐ adipocytokines. These substantially influence the mechanisms of insulin resistance and atherogenesis.
Summary		Izhodišča Sindrom policističnih ovarijev (PCOS) je pogosta endokrina bolezen pri ženskah v rodnem obdobju. Obstaja več različic definicije tega sindroma, za katerega so značilni predvsem klinični in/ali laboratorijski znaki androgenizacije in motnje v menstruacijskem ciklu. Zaključki Sindrom je jasno povezan z dejavniki tveganja za srčno-žilne bolezni, manj raziskana pa je dolgoročna ogroženost bolnic za obolevanje in umiranje za srčno-žilnimi boleznimi. V razvoju ateroskleroze pri PCOS je značilno prepletanje patogenetskih mehanizmov, ki povzročajo oziroma slabšajo endotelno disfunkcijo, predklinično obliko ateroskleroze, in inzulinsko rezistenco, osrednjo presnovno motnjo pri PCOS. Vse več je znanega tudi o vlogi sistema renin-angiotenzin-aldosteron. Več kot polovica bolnic s PCOS je debelih z značilnim visceralnim kopičenjem maščobe. Maščevje je pomemben endokrini organ, iz katerega se sproščajo številne presnovno aktivne snovi ‐ adipocitokini, ki se vpletajo v mehanizme razvoja inzulinske rezistence in ateroskleroze.
Descriptors		POLYCYSTIC OVARY SYNDROME ATHEROSCLEROSIS ENDOTHELIUM, VASCULAR INSULIN RESISTANCE CARDIOVASCULAR DISEASES RENIN-ANGIOTENSIN SYSTEM OBESITY ADIPOSE TISSUE