| Author/Editor | Bindas, Alenka; Novak-Antolič, Živa | |
| Title | Porodniški izid po konzervativni terapiji intraepitelijskih ali zgodnjih invazivnih lezij materničnega vratu: pregled podatkov za Slovenijo od leta 2002 do 2005 | |
| Translated title | Obstetric outcomes after conservative treatment for intraepitelial or early invasive cervical lesions: review for Slovenia, years 2002-2005 | |
| Type | članek | |
| Source | Zdrav Vestn | |
| Vol. and No. | Letnik 78, št. 5 | |
| Publication year | 2009 | |
| Volume | str. 241-6 | |
| Language | slo | |
| Abstract | Background Conservative methods to treat cervical intraepithelial neoplasia and microinvasive cervical cancer are commonly used in young women because of the advent of effective screening programmes. We investigated the effect of these procedures on subsequent pregnancy outcomes. Methods A retrospective study was perfomed. The study group compromised 69767 deliveries from National Perinatal Informational System of Slovenia (NPIS) between 2002 and 2005. We have one study group after cold knife conisation (750 women) and second after large loop excision of transformation zone; LLETZ (391 women). We calculated relative risks and 95 % confidence interval (CI). Results Cold knife conisation was significantly associated with preterm delivery before 37 weeks [relative risk (RR) 3.34; 95 % confidence interval (CI) 2.76‐4.02, 137/750 (18 %) vs 4333/69014 (6 %)] and low birthweight [< 2500g; RR 2.11, 95 % CI 1.69‐2.62, 94/760 (12 %) vs 4413/70248 (6 %)]. LLETZ was also significantly associated with preterm delivery [2.28; 1.70‐3.05; 53/391 (13 %) vs 4417/69369 (6 %)], low birthweight (1.72; 1.25 ‐2.37, 42/404 (10 %) vs 4465/70604 (6 %) (table 1). There were no differences in other neonatal outcomes. Conclusions All the excisional procedures to treat cervical intaepithelial neoplasia present similar pregnancy related morbidity without apparent neonatal morbidity. Coution in the treatment of young women with mild cervical abnormalities should be recommended. Clinicians now have the evidence base to counsel women appropriately. | |
| Descriptors | PREGNANCY COMPLICATIONS, NEOPLASTIC CERVICAL INTRAEPITHELIAL NEOPLASIA CERVIX NEOPLASMS CONIZATION LABOR, PREMATURE PREGNANCY OUTCOME |