Author/Editor		Gubina, M; Derganc, M; Čižman, M; Primožič, J
Title		Long term survey of bacterial isolates from CSF and their sensitivity to antibiotics
Type		članek
Source		Alpe Adria Microbiol J
Vol. and No.		Letnik 1, št. 1
Publication year		1992
Volume		str. 21-31
Language		eng
Abstract		During the 23-year period (1968-90), cerebrospinal fluid specimens were cultured and 2784 bacterial strains were isolated. Our main interest was the group of 3 bacteria: S. pneumoniae, N. meningitidis and H. influenzae representing 27.91 per cent of all isolates. Our results demonstrate a period of high incidence of N. meningitidis infections during the years 1968-74. Sensitivity tests were performed by disc-diffusion method. Six antibiotics: penicillin (PEN), ampicillin (AMP), erythromycin (ERY), cephalothin (LOT), cetotaxime (CFX) and chloramphenicol (CAP) were tested in the period 1968-90. 147 H. influenzae strains were isolated and a gradually increasing incidence was detected during the last decade. H. influenzae was resistant in 24 per cent to AMP and to CAP in 3.4 per cent . No resistant strains to AMP were found among S. pneumoniaue and N. meningitidis strains, but 2.6 per cent and 1 per cent were resistant to CAP restpectively. During 1976-83 period, 55 per cent of H. influenzae strains resistant to different tested antibiotics were found, but in the last period (1984-90), only 12 per cent of resistant H. influenzae strains were detected. During last three years, the rate of beta- lactamase production among H. influenzae strains was 7.4 per cent . The sensitivily study of S. pneumoniae, N. meningitidis and H. influenzae indicates that in meningitis caused by these bacteria, the third generation cephalosporins are the antibiotics of choice.
Descriptors		CEREBROSPINAL FLUID MENINGITIS, BACTERIAL PENICILLINS CEPHALOSPORINS CELLS, CULTURED DRUG RESISTANCE, MICROBIAL