| Author/Editor | Brunskole, Mojca; Lanišnik-Rižner, Tea; Stojan, Jure | |
| Title | Encimi iz naddružine kratkoverižnih dehidrogenaz/reduktaz kot nove farmakološke tarče | |
| Translated title | Enzymes of the short-chain dehydrogenase/reductase superfamily s new pharmacological targets | |
| Type | članek | |
| Source | Farm Vestn | |
| Vol. and No. | Letnik 60, št. 3 | |
| Publication year | 2009 | |
| Volume | str. 159-64 | |
| Language | slo | |
| Abstract | Short-chain dehydrogenases/reductases (SDR) constitute a large protein family. Although they have several structural features in common, they act on a highly diverse set of substrates. They are involved in metabolism of steroid hormones, fatty acids, alcohols, retinoids, prostaglandins and xenobiotics. Around 70 SDR members are identified within the human genome. In human body they participate in numerous distinct (patho)physiological processes, thus they are very interesting therapeutic targets for the treatment of genetic, hormone dependent and metabolic diseases like galactosemia, phenylketonuria, breast cancer, endometrium, prostate and colon cancer, dyslipidemia, obesity and arterial hypertension. | |
| Descriptors | OXIDOREDUCTASES METABOLIC DISEASES ENDOCRINE DISEASES |