Author/Editor		Vesel, Tina; Luzar, Boštjan; Calonje, Eduardo; Avčin, Tadej
Title		Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis
Type		članek
Source		J Cutan Pathol
Vol. and No.		Letnik 36
Publication year		2008
Volume		str. 991-4
Language		eng
Abstract		A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency who developed a syringotropic hypersensitivity reaction after 9 months of therapy with infliximab and leflunomide is described. Clinically, our patient showed a vasculitic-like skin rash involving both palms and soles, and histopathological examination revealed a syringotropic lymphocytic infiltrate directed toward the intra-epidermal portion of the eccrine ducts. These features have not been previously associated with infliximab or leflunomide therapy and represent a unique cutaneous hypersensitivity reaction that does not fit any known description of an immune-mediated hypersensitivity reaction. Vesel T, Luzar B, Calonje E, Avcin T. Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis.
Descriptors		ARTHRITIS, PSORIATIC ALPHA 1-ANTITRYPSIN SKIN MANIFESTATIONS HYPERSENSITIVITY ANTIBODIES, MONOCLONAL ADOLESCENCE TUMOR NECROSIS FACTOR