Author/Editor		Ortmann, Olaf; Čufer, Tanja; Dixon, J Michael; Maass, Nicolai; Marchetti, Paolo; Pagani, Olivia; Pronzato, Paolo; Semiglazov, Vladimir; Spano, Jean-Philippe; Vrdoljak, Eduard; Wildiers, Hans
Title		Adjuvant endocrine therapy for perimenopausal women with early breast cancer
Type		članek
Source		Breast
Vol. and No.		Letnik 18, št. 1
Publication year		2009
Volume		str. 2-7
Language		eng
Abstract		Adjuvant treatment with aromatase inhibitors (AIs) improves outcomes in postmenopausal women with hormone-sensitive early breast cancer compared with tamoxifen. However, AIs should not be used in premenopausal women because they can paradoxically increase estrogen secretion and may therefore stimulate tumor progression. In perimenopausal women undergoing treatment for breast cancer, it can be difficult to determine true menopausal status because adjuvant chemotherapy, tamoxifen, and gonadotropin-releasing hormone analogues can induce transient (or permanent) ovarian suppression. How can one determine whether these women are truly postmenopausal and therefore candidates for AI therapy? A panel of experts in the field of endocrine therapy in breast cancer met in Dubrovnik, Croatia, on October 23, 2006, to discuss this clinical dilemma. This report summarizes the conclusions and recommendations that arose from this discussion.
Descriptors		ADULT ANTINEOPLASTIC AGENTS, HORMONAL BREAST NEOPLASMS CHEMOTHERAPY, ADJUVANT NEOPLASMS, HORMONE-DEPENDENT OVARIECTOMY OVARY PATIENT SELECTION POSTMENOPAUSE TAMOXIFEN