Author/Editor     Bohanec-Grabar, Petra; Logar, Dušan; Tomšič, Matija; Rozman, Blaž; Dolžan, Vita
Title     Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients
Type     članek
Source     Dis Markers
Vol. and No.     Letnik 26, št. 1
Publication year     2009
Volume     str. 41-8
Language     eng
Abstract     Reactive oxygen and nitrogen species are involved in the pathology of rheumatoid arthritis (RA). Polymorphisms in genes coding for superoxide dismutases (SOD2 and SOD3), catalase (CAT), tumor necrosis factor-alpha (TNFA) and inducible NO synthase (NOS2A) may influence RA activity. We determined SOD2 Ala-9Val, SOD3 Arg213Gly, CAT C-262T, TNFA G-308A, TNFA C-857T and NOS2A (CCTTT) (n)polymorphisms in 327 RA patients. Carriers of CAT -262T and TNFA -308A allele had lower mean disease activity score of 28 joint count (DAS28) values than patients with CAT -262CC and TNFA -308GG genotypes (p = 0.014 and p = 0.046, respectively). Patients with the combination of CAT -262T and TNFA -308A allele had lower mean DAS28 values and a higher probability for low disease activity than non-carriers (p = 0.003, OR = 3.585, 95% CI = 1.538-8.357). Our results suggest that CAT and TNFA polymorphisms alone and in combination influence the activity of RA.
Descriptors     ARTHRITIS, RHEUMATOID
BASE SEQUENCE
CATALASE
DNA PRIMERS
GENETIC MARKERS
MICROSATELLITE REPEATS
MINISATELLITE REPEATS
OXIDATIVE STRESS
SUPEROXIDE DISMUTASE