Author/Editor		Janša, Karmen
Title		Povečana debelina intime-medije karotidnih arterij in dejavniki srčno-žilne ogroženosti žensk, ki so imele nosečnostno sladkorno bolezen
Translated title		Increased intima-media thickness of carotid arteries and cardiovascular risk factors in women with previous gestational diabetes mellitus
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 78, št. 8
Publication year		2009
Volume		str. 387-92
Language		slo
Abstract		Background Women with gestational diabetes mellitus (GDM) are at an increased risk of the development of type 2 diabetes. Cardiovascular disease is the main reason for the death of individuals with type 2 diabetes. The aim of the study was to find out if women with previous GDM already have the early signs of atherosclerosis and the components of cardiovascular disease. patients and We have compared the intima-media thickness (IMT) and metabolic and cardiovascular risk methods factors of 15 women being from three months to two years after delivery, with previous GDM to 9 post-gestational women with normal glucose tolerance. High-resolution ultrasonography for the noninvasive measurement of the intima-media thickness has been used. The IMT has been expressed as the mean of the three measurements of the far wall at three different sites of the carotid arteries (the common carotid artery, carotid bifurcation and internal carotid artery). The fasting blood glucose, HbA1c, lipid profile, resting blood pressure, waist circumference, body mass index and the smoking status have also been evaluated. Results Women with GDM (age 30.8 ± 6.0 years) compared to women with normal glucose tolerance (age 29.7 ± 2.9 years) have significantly increased IMT of all measured part of the carotid tree (mean left and right sites of the common carotid artery: 0.61 ± 0.08 mm in GDM vs. 0.53 ± 0.03 mm in control, p = < 0.05; carotid bifurcation: 0.85 ± 0.24 mm in GDM vs. 0.62 ± 0.1 mm in control, p = < 0.05; internal carotid artery: 0.66 ± 0.1 mm in GDM vs. 0.53 ± 0.1 mm in control, p = < 0.01). The two groups significantly differ from the body mass index, body waist circumference, in the level of fasting blood glucose and triglyceride, but there are no differences between the groups in the level of whole cholesterol, HDL in LDL cholesterol, systolic and diastolic blood pressure, HbA1c and smoking status. (Abstract truncated at 2000 characters)
Descriptors		CAROTID ARTERIES TUNICA INTIMA TUNICA MEDIA DIABETES, GESTATIONAL ATHEROSCLEROSIS BODY MASS INDEX BLOOD PRESSURE HEMOGLOBIN A, GLYCOSYLATED BLOOD GLUCOSE CHOLESTEROL TRIGLYCERIDES