Author/Editor		Smogavec, Mateja; Yagorac, Andreja; Kokalj-Vokač, Nadja
Title		Kromosomske nepravilnosti pri neplodnosti
Translated title		Chromosome abnormalities in infertility
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 78, št. 8
Publication year		2009
Volume		str. 393-8
Language		slo
Abstract		Background The aim of the current study was to find out the importance of chromosomal abnormalities in infertile patients, who were sent to Laboratory of medical genetics, University Clinical Centre Maribor, Maribor for kariotyping. The obtained results and the review of the literature are helpful in understanding the importance of cytogenetics analysis in infertility. Methods The cytogenetic data of infertility were collected from January 2000 to September 2008. The examined population of 750 people was divided in 290 infertile couples, infertile females (20) and infertile males (150). In all, a routine cytogenetics analysis from peripheral blood was made. 30 metaphase cells using GTG, RHG and/or RBG banding were analysed. Results Chromosomal abnormalities were found in 87 people (11.6 %; 6.8 % in men and 4.8 % in women). The percentage of chromosomal abnormalities in the studied population (8.8 %) correlates with the data in the literature. Conclusions Chromosomal analysis is an important method in diagnostic procedures of infertility, because chromosomal abnormalities could play the important role in etiology of infertility and are more frequently detected in this group of patients compared to general population.In the infertile couples balanced chromosomal abnormalities are the main cause of spontaneous abortions. Sex chromosome aneuploidies are highly correlated to infertility of females and males.
Descriptors		INFERTILITY KARYOTYPING CHROMOSOME ABNORMALITIES OLIGOSPERMIA AMENORRHEA