| Author/Editor | Fokter, Nina; Možina, Martin; Brvar, Miran | |
| Title | Potential drug-drug interactions and admissions due to drug-drug interactions in patients treated in medical departments | |
| Type | članek | |
| Source | Wien Klin Wochenschr | |
| Vol. and No. | Letnik 121 | |
| Publication year | 2009 | |
| Language | eng | |
| Abstract | Purpose: Adverse drug reactions due to drugdrug interactions (DDls) are important in drug safety.The aim of this study was to check potential DDls (pDDls) on hosp.ital ad mission and discharge and to evaluate admissions due to DDls in medical departments of a primary city and tertiary referral hospital.Methods: Age, sex, presence of renal and liver failure, drug information, diagnosis, and urgency and reason for admission were retrospectively recorded in 520 randomly selected patiems in medical departments of the University Medical Center Ljubljana. The screening program Drug-Reax was used to check for pDDls in patients with drug information on botb admission and discbarge home, and the proportlon of patients ad mitted as the consequence of a ODI was estimated.Results: Overall, 14.6% (76/520) of patients had incomplete information on drug names in their medical documentation on ad mission; at the end of treatment 12.5% (52/416) of patients were discharged home with incomplete information on drug names in their discharge letters. A total of 323 patients had complete information on drug names on both admission and dischargc and were included in the analysis ofpDDls: 51% (166/323) of patients on admission and 63% (204/323) on discharge had at least one pDDl (P = 0.001). Major pDDls were found in 13% (41/323) ofpatients on admission and 18% (59/323) on discharge (P = 0.001). An ACE inhibitor combined with spironolactone was the most common major pDDl, representing 20.0% of all pDDIs on admission and 25.6% on discharge. Among patients with pDDI on admission, 2.4% (4/166) of we re admitted because of an ADR caused by a DDI. Overall, 1.2% (4/323) of patients were admitted as the consequence of a DDI.Conclusions: The information on patient medication on hospital admission and discharge is incomplete.Balf of patients on ad mission and almost two-thirds on discharge had pDDIs. (Abstract truncated at 2000 characters) | |
| Descriptors | MEDICAL RECORDS DRUG INTERACTIONS DATA COLLECTION PATIENT ADMISSION PATIENT DISCHARGE HOSPITAL DEPARTMENTS HOSPITALS, UNIVERSITY |