Author/Editor     Leskovšek, V; Urleb, U
Title     Encimske metode za sintezo zdravilnih učinkovin
Translated title     Enzymatic methods for drug synthesis
Type     članek
Source     Farm Vestn
Vol. and No.     Letnik 45, št. 1
Publication year     1994
Volume     str. 3-14
Language     slo
Abstract     In this review some important enzymesm, used in drug synthesis, are presented. Esterases and lipases are widely used as biocatalysts for hydrolysis and esterifications. The synthesis of peptide bond is catalyzed by alpha-chymotrypsin, which belongs to the group of enzymes, named proteases. Oxudation and reduction reactions are catalyzed by oxydoreductases. Aldolases and synthases are the groups of enzymes, which are very specific. They catalyze only few reactions: aldol condensation is catalyzed by aldolase, the formation of beta-lactam ring of penicillin is enabled by N-penicillin synthase.
Descriptors     DRUGS
ENZYMES
STEREOISOMERS
ESTERASES
LIPASES
PEPTIDE PEPTIDOHYDROLASES
OXIDOREDUCTASES
LIGASES
FRUCTOSEDIPHOSPHATE ALDOLASE