Author/Editor		Gunde-Cimerman, N; Plemenitaš, A; Cimerman, A
Title		Pleurotus fungi produce mevinolin, an inhibitor of HMG CoA reductase
Type		članek
Source		FEMS MICROBIOL LETT
Vol. and No.		Letnik 113, št. 3
Publication year		1993
Volume		str. 333-7
Language		eng
Abstract		Fungi of the genus Pleurotus were shown to produce the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor mevinolin. Crude methanol extracts and the purified inhibitor from three different species, P. sapidus, P. saca and P. ostreatus, were tested using the solubilized microsomal HMGCoA reductase from Chinese hamster ovary cells. The identity of the inhibitor was also confirmed by thin layer chromatography, high pressure liquid chromatography and mass spectroscopy.
Descriptors		HYDROXYMETHYLGLUTARYL COA REDUCTASES LOVASTATIN POLYPORACEAE CRICETULUS CHO CELLS HAMSTERS LOVASTATIN