Author/Editor		Preželj, J; Kocijančič, A
Title		Antiandrogen treatment with spironolactone and linestrenol decreases bone mineral density in eumenorrhoeic women with androgen excess
Type		članek
Source		Horm Metab Res
Vol. and No.		Letnik 26, št. 1
Publication year		1994
Volume		str. 46-8
Language		eng
Abstract		Increased bone mineral density (BMD) has been reported in young women with androgen excess. To determine whether antiandrogen treatment in young women with androgen excess reduces BMD in these patients, the authors measured BMD before and a year after the beginning of antiandrogen therapy with spironolactone and linestrenol in 17 consecutive androgenized patients (median age 22 years). After a year's treatment BMD declined in 15 out of 17 patients, the mean decrease--0.032 g/cm2 (95 percent CI of the difference 0.016-0.048)--being highly significant (p less th. 0.001). Androstenedione decrease was the only hormonal variable significantly correlating with BMD decrease (r = 0.5; p = 0.037) according to simple linear regression. A decrease of BMD might become a key factor in deciding about the duration of antiandrogen treatment with spironolactone in functional hyperandrogenemia.
Descriptors		BONE DENSITY HYPERANDROGENISM LYNESTRENOL SPIRONOLACTONE ADULT LYNESTRENOL SPIRONOLACTONE