Author/Editor		Pečovnik-Balon, Breda; Hojs, Radovan; Jakopin, Eva; Rupreht, Mitja
Title		Srčnožilne kalcifikacije in ateroskleroza pri bolnikih s končno ledvično odpovedjo
Translated title		Cardiovascular calcifications and atherosclerosis in patients with end stage disease
Type		članek
Source		In: Križman I, editor. Zbornik predavanj 3. kongres Združenja internistov Slovenije; 2009 sep 25-26; Ljubljana. Ljubljana: Združenje internistov SZD,
Publication year		2009
Volume		str. 165-8
Language		slo
Abstract		Cardiovascular disease accounts for more than 50% of deaths among persons with end stage renal disease (ESRD). Atherosclerosis and vascular calcifications are also the consequence of non-traditional risk factors in haemodialysis patients. These are duration of haemodialysis treatment, serum calcium and phosphate, CaXP product, secundary hyperparathyroidism. Fetuin A and Matrix Gla protein are also important. Hypertension and arithmiae have also the influence. Pathogenic mehanism of cardiovascular calcifications in patients with chronic renal disease is explaned in the article. The conection with intima media thickness as atherosclerosis measurement is also explaned.
Summary		Srčnožilne bolezni (SŽB) so vzrok smrtnosti pri več kot 50% bolnikov s končno ledvično odpovedjo (KLO). Vzroka sta ateroskleroza in srčnožilne kalcifikacije, ki so posledica tudi netradicionalnih dejavnikov tveganja pri bolnikih zdravljenih z dializo. To so trajanje hemodializnega (HD) zdrav1jenja, serumski Ca in P, zmnožek Ca x P, sekundarni hiperparatiroidizem. Vlogo imata tudi fetuin-A in matriksni Gla protein. K razvoju SŽB prispevajo tudi arterijska hipertenzija in aritmije. V prispevku je razložen patogenetski mehanizem srčnožilnih kalcifikacij pri bolnikih s kronično ledvično boleznijo (KLB) in povezanost z debelino intime medije, kot merilom ateroskleroze.
Descriptors		CARDIOVASCULAR DISEASES ATHEROSCLEROSIS RENAL OSTEODYSTROPHY HYPERPARATHYROIDISM, SECONDARY