Author/Editor		Holc, Iztok; Gradišnik, Suzana; Pahor, Artur
Title		Zdravljenje vnetnih revmatskih bolezni z biološkimi zdravili - naše izkušnje
Translated title		Biological medication used in the treatment of inflammatory rheumatic diseases
Type		članek
Source		In: Križman I, editor. Zbornik predavanj 3. kongres Združenja internistov Slovenije; 2009 sep 25-26; Ljubljana. Ljubljana: Združenje internistov SZD,
Publication year		2009
Volume		str. 253-8
Language		slo
Abstract		Introduction: Rheumatoid arthritis (RA) is a chronic progressive inflammatory disease of multifactorial etiology. Cytokines, TNF-@ and interlevkines (IL-1 and IL-6) included, are a key factor of etiopathogenesis. They also play a significant role in the development of spondylarthritis (SpA). Recent evidence has now sparked a strong interest in B cells and their important role in the pathogenesis of RA. Aim: Our aim was to present the treatment of RA and SpA with biologicals on Dept. of rheumatology in UCC Maribor. Conclusions: The development of biologic drugs lead to significant progress in RA and SpA therapy. However, this therapy is associated with possible side effects that should be considered.
Summary		Uvod: Revmatoidni artritis (RA) je kronična progresivna vnetna bolezen multifaktorielne etiologije. Ključnega pomena pri etiopatogenezi so citokini; med njimi tudi faktor tumorske nekroze alfa (TNF-@@ @@ in tudi interlevkini (IL-1 in IL-6). Le-ti igrajo pomembno vlogo tudi pri razvoju spondiloartritisov (SpA). Pomembno vlogo v T celičnem odgovoru pri bolnikih z revmatoidnim artritisom imajo tudi visoko efektivne antigen predstavitvene B celice. Namen: Predstaviti zdravljenje RA in SpA z biološkimi zdravili na Oddelku za revmatologijo UKC Maribor. Zaključki: Razvoj bioloških zdravil je privedel do pomembnega napredka v zdravljenju RA in SpA. Vendar to zdravljenje spremljajo tudi možni stranski učinki, na katere je treba biti pozoren.
Descriptors		RHEUMATIC DISEASES TREATMENT OUTCOME