Author/Editor		Vercauteren, Jurgen; Wensing, Annemarie M; Poljak, Mario; Stanojević, Maja
Title		Transmission of drug-resistant HIV-1 is stabilizing in Europe
Type		članek
Source		J Infect Dis
Vol. and No.		Letnik 200, št. 10
Publication year		2009
Volume		str. 1503-8
Language		eng
Abstract		The SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793 patients in 20 European countries and in Israel with newly diagnosed human immunodeficiency virus type 1 (HIV-1) infection. The overall prevalence of TDR was 8.4% (225 of 2687 patients; 95% confidence interval [CI], 7.4%-9.5%), the prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) resistance was 4.7% (125 of 2687 patients; 95% CI, 3.9%-5.5%), the prevalence of nonucleoside reverse-transcriptase inhibitor (NNRTI) resistance was 2.3% (62 of 2687 patients; 95% CI, 1.8%-2.9%), and the prevalence of protease inhibitor (PI) resistance was 2.9% (79 of 2687 patients; 95% CI, 2.4%-3.6%). There was no time trend in the overall TDR or in NRTI resistance, but there was a statistically significant decrease in PI resistance (P = .04) and in NNRTI resistance after an initial increase (P = .02). We found that TDR appears to be stabilizing in Europe, consistent with recent reports of decreasing drug resistance and improved viral suppression in patients treated for HIV-1 infection.
Descriptors		HIV-1 HIV INFECTIONS DRUG RESISTANCE, MICROBIAL HIV-1 REVERSE TRANSCRIPTASE REVERSE TRANSCRIPTASE INHIBITORS HIV PROTEASE INHIBITORS GENOTYPE INCIDENCE PREVALENCE ODDS RATIO BASE SEQUENCE EUROPE PROSPECTIVE STUDIES