Author/Editor     Legan, Mateja; Luzar, Boštjan; Ferlan-Marolt, Vera
Title     Expression of cyclooxygenase-2, glucose transporter-1 and angiogenesis in gallbladder carcinomas and their impact on prognosis
Type     članek
Source     Scand J Gastroenterol
Vol. and No.     Letnik 44, št. 9
Publication year     2009
Volume     str. 1101-8
Language     eng
Abstract     Objective. To investigate the angiogenic and prognostic role of cyclooxygenase-2 (COX-2) in gallbladder carcinomas. We assume COX-2 overexpression, neoangiogenesis and glucose transporter-1 (GLUT-1) to be involved in disease progression. Material andmethods. The carcinoma tissues of 56 patients with gallbladder carcinomas were studied immunohistochemically for the expression of COX-2, GLUT-1 and micro-vessel density. The results were correlated with clinico-pathological features and survival/prognosis. Results. The overexpression of COX-2 in gallbladder carcinomas was significantly associated with increased angiogenesis and GLUT-1 expression. Neither angiogenesis nor the grade of the tumour correlate significantly with poor survival. Age, gender and a strong GLUT-1 expression were significant factors of adverse prognosis. Conclusions. Next to age and gender of patients, hypoxia of gallbladder tumours is a factor influencing survival. Among hypoxic factors, GLUT-1 expression is an important (significant) denominator of poor prognosis in gallbladder carcinomas, but not COX-2 nor angiogenesis.
Descriptors     GALLBLADDER NEOPLASMS
ADENOCARCINOMA
PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE
MONOSACCHARIDE TRANSPORT PROTEINS
NEOVASCULARIZATION, PATHOLOGIC
ANOXIA
IMMUNOHISTOCHEMISTRY
RETROSPECTIVE STUDIES