Author/Editor | Legan, Mateja; Luzar, Boštjan; Ferlan-Marolt, Vera | |
Title | Expression of cyclooxygenase-2, glucose transporter-1 and angiogenesis in gallbladder carcinomas and their impact on prognosis | |
Type | članek | |
Source | Scand J Gastroenterol | |
Vol. and No. | Letnik 44, št. 9 | |
Publication year | 2009 | |
Volume | str. 1101-8 | |
Language | eng | |
Abstract | Objective. To investigate the angiogenic and prognostic role of cyclooxygenase-2 (COX-2) in gallbladder carcinomas. We assume COX-2 overexpression, neoangiogenesis and glucose transporter-1 (GLUT-1) to be involved in disease progression. Material andmethods. The carcinoma tissues of 56 patients with gallbladder carcinomas were studied immunohistochemically for the expression of COX-2, GLUT-1 and micro-vessel density. The results were correlated with clinico-pathological features and survival/prognosis. Results. The overexpression of COX-2 in gallbladder carcinomas was significantly associated with increased angiogenesis and GLUT-1 expression. Neither angiogenesis nor the grade of the tumour correlate significantly with poor survival. Age, gender and a strong GLUT-1 expression were significant factors of adverse prognosis. Conclusions. Next to age and gender of patients, hypoxia of gallbladder tumours is a factor influencing survival. Among hypoxic factors, GLUT-1 expression is an important (significant) denominator of poor prognosis in gallbladder carcinomas, but not COX-2 nor angiogenesis. | |
Descriptors | GALLBLADDER NEOPLASMS ADENOCARCINOMA PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE MONOSACCHARIDE TRANSPORT PROTEINS NEOVASCULARIZATION, PATHOLOGIC ANOXIA IMMUNOHISTOCHEMISTRY RETROSPECTIVE STUDIES |