Author/Editor		Takač, I; Arko, D; Kodrič, T; Poljak, M; Zagorac, A; Erjavec-Škerget, A; Kokalj-Vokač, N
Title		Human telomerase gene amplification and high-risk human papillomavirus infection in women with cervical intra-epithelial neoplasia
Type		članek
Source		J Int Med Res
Vol. and No.		Letnik 37, št. 5
Publication year		2009
Volume		str. 1588-95
Language		eng
Abstract		This study was designed to investigate whether a correlation exists between amplification of the human telomerase gene (human telomerase RNA component [TERC]) and high-risk human papillomavirus (HR-HPV) infection in 101 women with cervical intra-epithelial neoplasia (CIN). Eight patients (7.9%) had CIN 1, 24 (23.8%) had CIN 2 and 69 (68.3%) had CIN 3. TERC was amplified in 31.7% of all CIN patients. The difference in frequency of TERC amplification between patients with low-grade CIN (CIN 1) and those with high-grade CIN (CIN 2 and CIN 3) was not significant. HR-HPV infection was detected in 88.1% of all CIN cases and was significantly more frequent in patients with CIN 2 and CIN 3 than in patients with CIN 1. There was no significant difference in the frequency of HR-HPV infection between groups of patients with and without TERC amplification. In conclusion, this study found no correlation between TERC amplification and HR-HPV infection in patients with CIN.
Descriptors		CERVICAL INTRAEPITHELIAL NEOPLASIA PAPILLOMAVIRUS, HUMAN TELOMERASE GENE AMPLIFICATION RNA PROBES POLYMERASE CHAIN REACTION VAGINAL SMEARS CONIZATION