Author/Editor		Miljković, Jovan
Title		Psoriza nohtov: možnosti zdravljenja
Translated title		Nail psoriasis: treatment modalities
Type		članek
Source		In: Miljković J, editor. Zbornik predavanj 6. Dermatološki dnevi; 2009 nov 6-7; Maribor. Maribor: Univerzitetni klinični center, Oddelek za kožne in spolne bolezni,
Publication year		2009
Volume		str. 83-7
Language		slo
Abstract		Nail psoriasis occurs in as many as 50 % of psoriatic patients, while the lifetime incidence of nail involvement has be estimated to be close to 90 %. Psoriasis limited to the nails comprises 1-5 % of psoriasis patients, in patients with psoriatic arthritis a frequency of approximately 85 % was found. The majority of patients had minor complaints but approximately 20 % had severe problems with involved nail. In many patients nail involvement causes functional impairment, pain, cosmetic problems and psychosocial embarrassment. Current treatment options for nail psoriasis are usually poorly efficacious. Relatively effective systemic treatments for nail psoriasis (cyclosporine, methotrexate and acitretin) have a serious toxicity potential. Preliminary data showed good results of biologic agents in the treatment of nail psoriasis.
Summary		Psoriatične spremembe na nohtih so prisotne pri približno polovici bolnikov, ocenjuje se, da se tekom življenja pojavijo približno pri 90 % obolelih z luskavico. Izolirane psoriatične spremembe na nohtih so prisotne le pri 1-5 % bolnikov, pri bolnikih s psoriatičnim artritisom pa približno pri 85 % bolnikov. Večina bolnikov s spremembami na nohtih nima večjih težav, okrog 20 % bolnikov ima bolečine, težave pri delu in trpi zaradi neestetskega videza. Obstoječi načini lokalnega zdravljenja psoriatično spremenjenih nohtov niso posebej učinkoviti, relativno učinkovito sistemsko zdravljenje s ciklosporinom, metotreksatom in acitretinom pa pogosto povzroča številne stranske učinke. Preliminarni podatki kažejo zelo dober učinek zdravljenja psoriaze nohtov z biološkimi zdravili.
Descriptors		PSORIASIS NAIL DISEASES DRUG THERAPY