Author/Editor     Leskovšek, V; Pečar, S
Title     Ključni encimi deoksiribonukleinske kisline kot mesto delovanja učinkovin
Translated title     Some important DNA enzymes as drug target
Type     članek
Source     Farm Vestn
Vol. and No.     Letnik 44, št. 3
Publication year     1993
Volume     str. 103-18
ISSN     0014-8229
Language     slo
Abstract     In this review some important DNA enzymes and drugs, affecting on them have been presented. DNA polymerases, DNA methyltransferases and DNA topoisomerases are target of many antimicrobial and antitumor drugs. So the quinolones, as chemotherapeutics, are inhibitors of a group of bacterial DNA topoisomerases - DNA gyrases. The substances, which are also important for further development of antibacterial drugs, have been described.
Descriptors     DNA POLYMERASES
DNA MODIFICATION METHYLASES
DNA TOPOISOMERASE
DNA TOPOISOMERASE (ATP-HYDROLYSING)
ANTINEOPLASTIC AGENTS
ACYCLOVIR
ENZYME INHIBITORS