Author/Editor		Brunskole, Mojca; Lanišnik-Rižner, Tea; Stojan, Jure
Title		Antimikotiki: sedanje in nove možnosti zdravljenja glivičnih okužb
Translated title		Antimycotics: current and novel strategies for treatment of fungal infections
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 60, št. 6
Publication year		2009
Volume		str. 295-302
Abstract		Antifungal treatment is becoming more and more important as the incidence of invasive fungal infections is increasing. Currently, several antimycotics with diverse mechanisms of action are available, but their usage is often limited by their adverse effects and resistance. Novel strategies for the treatment of fungal infections are as follows: high-dose therapy, modulation of the pharmacokinetic properties of the drugs, combination therapy, immune system enhancement, and the development of new antifungal agents. Ideal antimycotics would have selectivity to fungal cells, low rates of resistance, broad antifungal activity, reduced toxicity and improved efficacy. The most promising antifungals are those targeting fungal cell wall components, protein biosynthesis and signaling pathways.
Descriptors		MYCOSES ANTIFUNGAL AGENTS DRUG RESISTANCE, MICROBIAL