Author/Editor | Marinšek, Martin; Sinkovič, Andreja | |
Title | A randomized trial comparing the effect of ramipril and losartan in survivors of ST-elevation myocardial infarction | |
Type | članek | |
Source | J Int Med Res | |
Vol. and No. | Letnik 37, št. 5 | |
Publication year | 2009 | |
Volume | str. 1577-87 | |
Language | eng | |
Abstract | This study investigated the effect of 8 weeks of treatment with ramipril or losartan on N-terminal pro-brain natriuretic peptide (NT-proBNP) plasma levels, plasminogen activator inhibitor-1 (PAI-1) activity, echocardiographic parameters and lipid profiles in patients after acute myocardial infarction (MI). Patients were randomly assigned to receive up to 10 mg/day ramipril (n=27) or up to 100 mg/day losartan (n = 26). No significant differences in any of the tested variables were observed between the two treatment groups, either before or after treatment. Within the losartan-treated group a significant decrease in levels of NT-proBNP (211.1 +/- 211.5 versus 94.7+/- 150.1 pg/ml), total cholesterol (5.7 +/- 1.0 versus 4.6 +/- 1.1 mmol/l), and low-density lipoprotein-cholesterol (3.5 +/- 0.9 versus 2.7 +/- 1.0 mmol/l) was observed after treatment compared with baseline. Thus, after an acute MI, losartan seems equal to ramipril in terms of the NT-proBNP levels, echocardiographic parameters, PAI-1 activity and lipid profiles that were achieved. | |
Descriptors | MYOCARDIAL INFARCTION RAMIPRIL RAMIPRIL ANGIOTENSIN-CONVERTING ENZYME INHIBITORS RECEPTORS, ANGIOTENSIN PLASMINOGEN ACTIVATOR INHIBITOR 1 LIPIDS ECHOCARDIOGRAPHY |