Author/Editor		Irman-Florjanc, T; Erjavec, F
Title		Histamine tele-methylhistamine ratios in rat blood as a function of time after i.v. injection of compound 48/80 or histamine
Type		članek
Source		Agents Actions
Publication year		1992
Volume		str. C394-7
Language		eng
Abstract		The pharmacokinetic characteristics of histamine (Hi) and tele-methylhistamine (MeHi) were studied by following their concentrations in rat blood by HPLC after i.v. injection of Hi or compound 48/80. Both injected substances caused a significant elevation of Hi as well as MeHi levels in the blood. The ehmination curves for Hi showed two phases and significant differences depending on the injected substance. Following Hi injection, blood MeHi reached a maximum within 10-30 min and returned to baseline after about 50 mm. (Hi reached baseline after 15 min.) Following injection of compound 48/80, Hi reached a maximum at 10-15 min and MeHi at 40-45 min. It can be suggested that the signifcanoe of Hi or MeHi data in the circulating blood depends on the time which elapses from the maximal Hi concentration in the blood.
Descriptors		HISTAMINE METHYLHISTAMINES RATS COMPOUND 48-80 TIME FACTORS