Author/Editor		Berginc, Gašper; Bračko, Matej; Glavač, Damjan
Title		MS-MLPA reveals progressive age-dependent promoter methylation of tumor suppressor genes and possible role of IGSF4 gene in colorectal carcinogenesis of microsatellite instable tumors
Type		članek
Source		Cancer Invest
Vol. and No.		Letnik 28, št. 1
Publication year		2010
Volume		str. 94-102
Language		eng
Abstract		In 43 MSI-H colorectal cancers we searched for new targets of promoter methylation, inspected the nature of methylation process, and the influence of methylation at specific CpG site on gene expression. CpG methylation was detected in 12 tumor suppressor genes. Our findings suggest a potential role of IGSF4 gene in the development of colorectal tumors. According to the detected methylation pattern, two groups of tumors, significantly differing in age, exist in MSI-H colorectal cancers. Our study also suggests that methylation at a specific CpG island in the promoter could be the representative for gene silencing and therefore serve as a biomarker.
Descriptors		DNA METHYLATION GENE EXPRESSION REGULATION, NEOPLASTIC ADENOCARCINOMA AGE FACTORS AGED AGED, 80 AND OVER AGING COLORECTAL NEOPLASMS CPG ISLANDS IMMUNOGLOBULINS MEMBRANE PROTEINS