Author/Editor		Sher, A; Veber, M; Marolt-Gomišček, M; Gomišček, S
Title		The study of complexation of copper (II) ions with ampicillin: II. Dynamics of reactions
Type		članek
Source		Int J Pharm
Vol. and No.		Letnik 99
Publication year		1993
Volume		str. 119-23
Language		eng
Abstract		In the presence of ampicillin copper(II) ions form different coordination compounds. Their formation and the properties of particular species were examined by means of UV, Vis and IR spectrometry. The dynamics of complex formation was studied. Firstly, an unstable blue-violet coordination compound with an absorption maximum at 590 nm was formed, later being transformed into a more stable compound. Hydrolysis of the beta-lactam group is promoted by copper(II) and/or hydroxide ions and as a result the ampicillin ligand (L) is transformed into ampicilloic acid (L). Consequently, the coordination compounds (CuL)+, CuL2, (CuL3)- are changed to (CuL)+, CuL2 and (CuL3)-, respectively.
Descriptors		AMPICILLIN COPPER DRUG INTERACTIONS SPECTRUM ANALYSIS CHELATING AGENTS