Author/Editor		Barrett, Jeffrey C; Clayton, David G; Concannon, Patrick; Battelino, Tadej
Title		Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Type		članek
Source		Nature Genetics
Vol. and No.		Letnik 41, št. 6
Publication year		2009
Volume		str. 703-7
Language		eng
Abstract		Type 1 diabetes (T1D) is a common autoimmune disorder thatarises from the action of multiple genetic and environmental risk factors. We report the ?ndings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (Po 10?6). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (Po 0.01; overallPo 5? 10?8)and4additional regions provided nominal evidence of replication (Po 0.05). The many new candidate genes suggested by these results includeIL10,IL19,IL20,GLIS3,CD69 andIL27.
Descriptors		DIABETES MELLITUS, INSULIN-DEPENDENT GENOTYPE META-ANALYSIS MULTICENTER STUDIES GENOME, HUMAN