Author/Editor		Berce, Vojko; Krajnc, Ivan; Potočnik, Uroš
Title		Biološka zdravila pri zdravljenju astme
Translated title		Biologic drugs in asthma treatment
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 49, št. 1
Publication year		2010
Volume		str. 11-8
Language		slo
Abstract		Development of the new antiasthmatic drugs is directed ab ove all in the synthesis of the inhibitors of the proinflammatory cytokines and IgE antibodies. Several biologic drugs are tested for this purpose; most common of them are monoclonal antibodies or modified receptol-s. Experiments were also do ne with antiinflammatory cytokines, chemokine inhibitors, antilymphocytic antibodies, cell adhesion blockers and CpG oligonucleotides. The most promising drugs are those directed against interleukines IL-4, IL-S, IL-13, cytokine TNFa and IgE immunoglobulin. Humanized monoclonal antibody directed against immunoglobulin E binding site is the only biologic drug which is already us ed in the asthma treatment. Better understanding of the molecular mechanisms of asthma leads to the identification of the new therapeutic targets.
Descriptors		ASTHMA ANTIBODIES, MONOCLONAL IGE INTERLEUKIN-5 INTERLEUKIN-4 INTERLEUKIN-10 INTERLEUKIN-13 TUMOR NECROSIS FACTOR INFLAMMATION MEDIATORS