Author/Editor		Hudler, Petra
Title		Molekularni mehanizmi tvorbe zasevkov
Translated title		Molecular mechanisms of metastasis
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 49, št. 1
Publication year		2010
Volume		str. 63-76
Language		slo
Abstract		The spread of metastases from a primary site through blood or the lymphatic system, which results in the establishment of secondary tumors in distant locations, is the main cause of death in cancer patients. Recent molecular and clinical studies have expanded knowledge of mechanisms implicated in metastasis formation. The development of cells with metastatic potential requires a coordinated expression and function of genes in both tumor cells and cells from surrounding tissues. All of the events involved in the metastatic cascade (Le. angiogenesis, adhesion, migration, invasion, and growth) also play an important role in normal biological processes, such as reproduction, embryogenesis, wound healing, smooth muscle cell migration, lymphocyte trafficking and liver regeneration. The identification of molecules and signal pathways that contribute to metastasis is important for developing novel diagnostic and/or prognostic tests and for discovering novel therapeutic strategies to combat metastatic disease.
Descriptors		NEOPLASMS NEOPLASM METASTASIS SIGNAL TRANSDUCTION NEOPLASM INVASIVENESS LYMPHATIC METASTASIS TUMOR MARKERS, BIOLOGICAL