Author/Editor     Kotnik, P; Debeljak, M; Avbelj, M; Hovnik, T; Uršič-Bratina, N; Kržišnik, C; Battelino, T
Title     Lack of association of common allelic variants in the thyroglobulin gene with Hashimoto's thyroiditis in young subjects with type 1 diabetes
Type     članek
Source     Horm Res Paediatr
Vol. and No.     Letnik 73, št. 4
Publication year     2010
Volume     str. 244-7
Language     eng
Abstract     Background/Aim: Four SNPs (E10SNP24, E10SNP158, E12SNP, E33SNP) in the Tg gene are suspected to be involved in the development of autoimmune thyroid diseases. The aim of the study was to determine whether these variants play a role in the development of Hashimoto's thyroiditis in young subjects with type 1 diabetes, in whom autoimmune thyroid diseases are significantly more common than in the general population. Subjects and methods: Seventy-six subjects with type 1 diabetes and Hashimoto's thyroiditis and 110 subjects with only type 1 diabetes were studied. Hashimoto's thyroiditis was determined according to the clinical, biochemical and ultrasonographic criteria. SNPs were determined by the TaqMan SNP method. Results: In young subjects with type 1 diabetes, no association between any of the tested SNPs or their combinations and Hashimoto's thyroiditis was found. Conclusions: This is the first study to investigate the association of SNPs located inside the coding region of the Tg gene with the development of Hashimoto's thyroiditis in subjects with type 1 diabetes. The lack of an association is in concordance with a study where marker Tgms2, located inside intron 27, was not associated with joint susceptibility for autoimmune thyroid disease and type 1 diabetes.
Descriptors     THYROIDITIS, AUTOIMMUNE
THYROGLOBULIN
ALLELES
DIABETES MELLITUS, INSULIN-DEPENDENT