| Author/Editor | Benedik, Janez; Koželj, Gordana; Manohin, Aleksander | |
| Title | A study of midazolam plasma concentrations in patients undergoing conscius sedation | |
| Type | članek | |
| Source | Acta Chim Slov | |
| Vol. and No. | Letnik 57, št. 1 | |
| Publication year | 2010 | |
| Volume | str. 206-11 | |
| Language | eng | |
| Abstract | We studied midazolam plasma concentrations in patients undergoing middle ear surgery (MES) in local anesthesia and sedation. This study was based on the dinical measurement of the level of sedation and determination of the sedation dose of midazolam. For optimallevel of sedation for this type of surgery we suggest the midazolam plasma concentrations with median of 0.03 mg L -1 and range from 0.01-0.10 mg L -1. This can be contrasted to the other studies where considerably higher plasma concentrations of midazolam (0.2 mg L-1) were proposed (S. Michalk et al., Intens. Care Med. 1988, 15, 37-41). Despite low midazolam concentrations the level of sedation was adequate. | |
| Descriptors | TYMPANOPLASTY STAPES SURGERY CONSCIOUS SEDATION MIDAZOLAM ANESTHESIA, LOCAL ADULT CHROMATOGRAPHY, GAS SPECTRUM ANALYSIS, MASS |