Author/Editor | Velnar, Tomaž; Smrdel, Uroš; Popović, Mara; Bunc, Gorazd | |
Title | Genetic markers in oligodendroglial tumours | |
Type | članek | |
Source | Radiol Oncol | |
Vol. and No. | Letnik 44, št. 1 | |
Publication year | 2010 | |
Volume | str. 13-8 | |
Language | eng | |
Abstract | Background. Oliogodendrogliomas are brain tumours composed of the cells resembling oligodendrocytes. They represent the third most common glial tumour, comprising 2.5% of all primary brain tumours and 5-20% of all gliomas. Conclusions. Oligodendroglial tumours with 1p and 19q loss demonstrate a better overall prognosis due to more indolent clinical behaviour and higher sensitivity to treatment. Additionally, 1p and 19q loss is a marker of clinical utility, helping to assess tumour sensitivity to chemotherapy and harbouring the potential for improving the diagnosis and survival of oligodendroglioma patients as well as future clinical practice. | |
Descriptors | OLIGODENDROGLIA NEOPLASMS GENETIC MARKERS |