Author/Editor		Hammami, H; Zaraa, I; El, Euch; Chelly, I; Haouet, S; Mokni, M; Osman, AB
Title		Letterer-Siwe disease associated with chronic myelomyonocytic leukemia: a fortuitous association?
Type		članek
Source		Acta Dermatovenerol Alp Panonica Adriat
Vol. and No.		Letnik 19, št. 1
Publication year		2010
Volume		str. 45-8
Language		eng
Abstract		Langerhans cell histiocytosis (LCH) and malignancy occurring in the same individual is unusual and has generally been the subject of isolated case reports. LCH is a rare condition in adults. Its cause is uncertain but, with the recent demonstration of clonality and its association with malignant disease, there has been a renewal of interest. We report a singular case of Letterer-Siwe disease associated with a chronic myelomonocytic leukemia developing in an elderly woman. The simultaneous occurrence of both malignant disorders supports the hypothesis of a common genetic origin.