Author/Editor		Szekeres-Bartho, Julia; Kinsky, R; Kapović, M; Chaouat, G
Title		Complete Freund adjuvant treatment of pregnant females influences resorption rates in CBA/J x DBA/2 matings via progesterone-mediated immunomodulation
Type		članek
Source		Am J Reprod Immunol
Vol. and No.		Letnik 26, št. 2
Publication year		1991
Volume		str. 82-3
Language		eng
Abstract		Treatment of pregnant CBA/J females with CFA at day 0.5 and 7.5 of pregnancy significantly reduced the fetal resorption rates from 45% to 29% (P less than 0.05). Supernatants of progesterone-treated spleen cells from CFA treated CBA/J females pregnant of DBA/2 males significantly reduced natural cytotoxicity, while those of untreated identically pregnant mice had no effect. Supernatants of CFA-treated virgin mice blocked natural cytotoxicity to the same extent as those of CFA-treated pregnant mice. These data suggest that nonspecific immunostimulation induces progesterone receptors in spleen cells of CBA mice and that these receptors allow a progesterone dependent suppressive pathway to exert an antiresorptive effect.
Descriptors		ANIMALS FETAL RESORPTION FREUND'S ADJUVANT MICE MICE, INBRED CBA MICE, INBRED DBA PREGNANCY PROGESTERONE RECEPTORS, PROGESTERONE SPLEEN