Author/Editor		Erdani-Kreft, Mateja; Hudoklin, Samo; Jezernik, Kristijan; Romih, Rok
Title		Formation and maintenance of blood-urine barrier in urothelium
Type		članek
Source		Protoplasma
Vol. and No.		Letnik 246, št. 1-4
Publication year		2010
Volume		str. 3-14
Language		eng
Abstract		Blood-urine barrier, which is formed during differentiation of superficial urothelialcells, is the tightest and most impermeable barrier in the body. In the urinary bladder, the barrier must accommodate large changes in the surface area during distensions and contractions of the organ. Tight junctions and unique apical plasma membrane of superficial urothelial cells play a critical role in the barrier maintenance. Alterations in the blood-urine barrier function accompany most of the urinary tract diseases. In this review we discuss our and other most recent discoveries on the role of tight junctions, dynamics of Golgi apparatus and post-Golgi compartments, and intracellular membrane traffic during the biogenesis and maintenance of blood-urine barrier.
Descriptors		UROTHELIUM BLADDER TIGHT JUNCTIONS CELL MEMBRANE PERMEABILITY GOLGI APPARATUS INTRACELLULAR MEMBRANES CELL DIFFERENTIATION BLOOD ENDOCYTOSIS