Author/Editor		Vranič, Andrej
Title		Antigen expression on recurrent meningioma cells
Translated title		Izraženost antigenov pri ponavljajočih se meningiomih
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 44, št. 2
Publication year		2010
Volume		str. 107-12
Language		eng
Abstract		Introduction. Meningiomas are intracranial brain tumours that frequently recur. Recurrence rates up to 20% in 20 years for benign meningiomas, up to 80% for atypical meningiomas and up to 100% for malignant meningiomas, have been reported. The most important prognostic factors for meningioma recurrence are meningioma grade, meningioma invasiveness and radicality of neurosurgical resection. The aim of our study was to evaluate the differences in antigenic expression on the surface of meningioma cells between recurrent and non-recurrent meningiomas. Methods. 19 recurrent meningiomas and 35 non-recurrent meningiomas were compared regarding the expression of MIB-1 antigen, progesterone receptors, cathepsin B and cathepsin L, using immunohistochemistry. Results. MIB-1 antigen expression was higher in the recurrent meningioma group (p=0.001). No difference in progesterone receptor status between recurrent and non-recurrent meningiomas was confirmed. Immunohistochemical intensity scores for cathepsin B (p= 0.007) and cathepsin L (p<0.001) were both higher in the recurrent than in the non-recurrent meningioma group. Conslusions. MIB-1 antigen expression is higher in recurrent compared to non-recurrent meningiomas. There is no difference in expression of progesterone receptors between recurrent and non-recurrent meningiomas. Cathepsins B and L are expressed more in recurrent meningiomas.
Descriptors		MENINGIOMA MENINGEAL NEOPLASMS NEOPLASM RECURRENCE, LOCAL ANTIGENS, NEOPLASM RECEPTORS, PROGESTERONE IMMUNOHISTOCHEMISTRY CATHEPSINS RETROSPECTIVE STUDIES