Author/Editor		Furlan, Danijela; Ilijaš-Trofenik, Ana; Weber, Vladimir; Felc, Zlata; Bratanič, Borut; Lukač-Bajalo, Jana
Title		Bilirubin v popkovnični krvi kot napovednik neonatalne hiperbilirubinemije
Translated title		Cord blood bilirubin as a predictor of neonatal hyperbilirubinemia
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 79, št. 6
Publication year		2010
Volume		str. 482-7
Language		slo
Abstract		Background: Bilirubin is an antioxidant that protects newborns against free radicals during the first days of their lives, but at high levels is neurotoxic and causes brain damage. In this study we aimed to determine whether the measurement of bilirubin level in noninvasively taken cord blood could be a predictor of a pathologic al jaundice requiring medical treatment. Methods: Cord blood and a control sample taken dn the third day of life were taken from 185 healthy fulI- term newborns of both genders. Bilirubin levels were determined according to the Jandrassik-Grof method. Statistical characteristics were calculated using statistic programs ANOVA and t-test. ResuIts: 117 (63.2%) of the newborns had physiological jaundice with 28 +- 7.8 micromol/L bilirubin in cord bIo od, and 68 (36.8%) had pathological jaundice with 35 +- 7.8 micromol/L bilirubin. 20 (10.8%) newborns had been treated by phototherapy, and had levels of 40 +- 8.5 micromol/L bilirubin. Differences in cord blood bilirubin levels between groups were statistically significant (p < 0.001). Taking a cut-off value of 28 micromol/L cord bIood bilirubin level, pathological jaundice can be predicted by 85.3% and whether newborns require treatment or not by 100% clinica! sensitivity. Conclusions: The results of our study confirm that measurement of cord blood bilirubin level can be used as a screening test for predicting the development of pathological jaundice that requires medical treatment.
Descriptors		JAUNDICE, NEONATAL HYPERBILIRUBINEMIA FETAL BLOOD BILIRUBIN INFANT, NEWBORN